ProSci

DR1 Antibody

Product Code:
 
PSI-59-460
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
1 / 2
Western blot analysis in K562 cell line lysates (35ug/lane).
2 / 2
Western blot analysis in mouse kidney tissue lysates (35ug/lane).
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Western blot analysis in K562 cell line lysates (35ug/lane).
Western blot analysis in mouse kidney tissue lysates (35ug/lane).

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PSI-59-460-400ul400ul£626.00
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Further Information

Additional Names:
Protein Dr1, Down-regulator of transcription 1, Negative cofactor 2-beta, NC2-beta, TATA-binding protein-associated phosphoprotein, DR1
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
Background References:
  • Corneveaux, J.J., et al. Hum. Mol. Genet. 19(16):3295-3301(2010)
  • Kantidakis, T., et al. Nucleic Acids Res. 38(4):1228-1239(2010)
  • Albert, T.K., et al. Genome Biol. 11 (3), R33 (2010) :
  • Kahle, J., et al. J. Biol. Chem. 284(14):9382-9393(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Chicken, Rat
Immunogen:
This DR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-112 amino acids from the Central region of human DR1.
NCBI Gene ID #:
1810
NCBI Official Name:
Protein Dr1
NCBI Official Symbol:
DR1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
19 kDa
Protein Accession #:
Q01658
Protein GI Number:
401162
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q01658
User NOte:
Optimal dilutions for each application to be determined by the researcher.