Cdc14 Antibody
| Code | Size | Price |
|---|
| PSI-63-472-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Dual specificity protein phosphatase CDC14A, CDC14 cell division cycle 14 homolog A, CDC14A
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.
Background References:
- Kaiser,B.K., et al. Mol. Biol. Cell 13 (7), 2289-2300 (2002)
- Mailand,N., et al. Nat. Cell Biol.(4), 317-322 (2002)
- Bembenek,J. and Yu,H. J. Biol. Chem. 276 (51), 48237-48242 (2001)
- Li,L., et al. J. Biol. Chem. 275 (4), 2410-2414 (2000)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This Cdc14 antibody is generated from rabbits immunized with a recombinant protein encoding aa 1~379 of human cdc14.
NCBI Gene ID #:
8556
NCBI Official Name:
Dual specificity protein phosphatase CDC14A
NCBI Official Symbol:
CDC14A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
67 kDa
Protein Accession #:
Q9UNH5
Protein GI Number:
55976620
Purification:
This antibody is purified through a protein A column, followed by dialysis against PBS
Research Area:
Cell Cycle
Swissprot #:
Q9UNH5
User NOte:
Optimal dilutions for each application to be determined by the researcher.