MYH7 Antibody
| Code | Size | Price |
|---|
| PSI-59-342-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Myosin-7, Myosin heavy chain 7, Myosin heavy chain slow isoform, MyHC-slow, Myosin heavy chain, cardiac muscle beta isoform, MyHC-beta, MYH7, MYHCB
Application Note:
For WB starting dilution is: 1:1000
Background:
Muscle myosin is a hexameric protein containing 2 heavy
chain subunits, 2 alkali light chain subunits, and 2 regulatory
light chain subunits. This gene encodes the beta (or slow) heavy
chain subunit of cardiac myosin. It is expressed predominantly in
normal human ventricle. It is also expressed in skeletal muscle
tissues rich in slow-twitch type I muscle fibers. Changes in the
relative abundance of this protein and the alpha (or fast) heavy
subunit of cardiac myosin correlate with the contractile velocity
of cardiac muscle. Its expression is also altered during thyroid
hormone depletion and hemodynamic overloading. Mutations in this
gene are associated with familial hypertrophic cardiomyopathy,
myosin storage myopathy, dilated cardiomyopathy, and Laing
early-onset distal myopathy.
Background References:
- Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) :
- Eijgelsheim, M., et al. Hum. Mol. Genet. 19(19):3885-3894(2010)
- Millat, G., et al. EurMed Genet 53(5):261-267(2010)
- Muelas, N., et al. Neurology 75(8):732-741(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This MYH7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-211 amino acids from the N-terminal region of human MYH7.
NCBI Gene ID #:
4625
NCBI Official Name:
Myosin-7
NCBI Official Symbol:
MYH7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
223 kDa
Protein Accession #:
P12883
Protein GI Number:
83304912
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Immunology,Signal Transduction
Swissprot #:
P12883
User NOte:
Optimal dilutions for each application to be determined by the researcher.