CACNA2D2 Antibody

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ProSci
Product Code: PSI-57-021
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-57-021-400ul400ul£662.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunofluorescence (IF)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western Blot at 1:2000 dilution + human testis lysate Lysates/proteins at 20 ug per lane.
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Western Blot at 1:2000 dilution + mouse kidney lysate Lysates/proteins at 20 ug per lane.
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CACNA2D2 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
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Western Blot at 1:2000 dilution + human testis lysate Lysates/proteins at 20 ug per lane.
Western Blot at 1:2000 dilution + mouse kidney lysate Lysates/proteins at 20 ug per lane.
CACNA2D2 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.

Documents

Further Information

Additional Names:
Voltage-dependent calcium channel subunit alpha-2/delta-2, Voltage-gated calcium channel subunit alpha-2/delta-2, Voltage-dependent calcium channel subunit alpha-2-2, Voltage-dependent calcium channel subunit delta-2, CACNA2D2, KIAA0558
Application Note:
For WB starting dilution is: 1:2000

For IF starting dilution is: 1:10~50

For IHC-P starting dilution is: 1:10~50
Background:
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
Background References:
  • Donato, R., et al. J. Neurosci. 26(48):12576-12586(2006) Ivanov, S.V., et al. Am. J. Pathol. 165(3):1007-1018(2004) Carboni, G.L., et al. Oncogene 22(4):615-626(2003) Honorio, S., et al. Mol. Cell. Probes 15(6):391-393(2001) Angeloni, D., et al. Mol. Cell. Probes 15(2):125-127(2001)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CACNA2D2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 643-671 amino acids from the Central region of human CACNA2D2.
NCBI Gene ID #:
9254
NCBI Official Name:
Voltage-dependent calcium channel subunit alpha-2/delta-2
NCBI Official Symbol:
CACNA2D2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
130 kDa
Protein Accession #:
Q9NY47
Protein GI Number:
387912827
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Neuroscience,Signal Transduction
Swissprot #:
Q9NY47
User NOte:
Optimal dilutions for each application to be determined by the researcher.