ALOXE3 Antibody
| Code | Size | Price |
|---|
| PSI-55-184-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Hydroperoxide isomerase ALOXE3, Epidermis-type lipoxygenase 3, Epidermal LOX-3, e-LOX-3, eLOX-3, Hydroperoxy icosatetraenoate dehydratase, ALOXE3
Application Note:
For WB starting dilution is: 1:1000
Background:
ALOXE3 is a member of the lipoxygenase family, which
are catabolized by arachidonic acid-derived compounds. The encoded
enzyme is a hydroperoxide isomerase that synthesizes a unique type
of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic
acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This
epoxy alcohol can activate the the nuclear receptor peroxisome
proliferator-activated receptor alpha (PPARalpha), which is
implicated in epidermal differentiation. Loss of function of the
enzyme encoded by this gene results in ichthyosis, implicating the
function of this gene in the differentiation of human skin.
Background References:
- Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
- Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)
- Vahlquist, A., et al. J. Invest. Dermatol. 130(2):438-443(2010)
- Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 18(5):1651-1658(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ALOXE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-252 amino acids from the Central region of human ALOXE3.
NCBI Gene ID #:
59344
NCBI Official Name:
Hydroperoxide isomerase ALOXE3
NCBI Official Symbol:
ALOXE3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
81 kDa
Protein Accession #:
Q9BYJ1
Protein GI Number:
27923803
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Obesity,Signal Transduction
Swissprot #:
Q9BYJ1
User NOte:
Optimal dilutions for each application to be determined by the researcher.