GCLC Antibody
| Code | Size | Price |
|---|
| PSI-59-915-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Glutamate--cysteine ligase catalytic subunit, GCS heavy chain, Gamma-ECS, Gamma-glutamylcysteine synthetase, GCLC, GLCL, GLCLC
Application Note:
For WB starting dilution is: 1:1000
Background:
Glutamate-cysteine ligase, also known as
gamma-glutamylcysteine synthetase is the first rate-limiting enzyme
of glutathione synthesis. The enzyme consists of two subunits, a
heavy catalytic subunit and a light regulatory subunit. This locus
encodes the catalytic subunit, while the regulatory subunit is
derived from a different gene located on chromosome 1p22-p21.
Mutations at this locus have been associated with hemolytic anemia
due to deficiency of gamma-glutamylcysteine synthetase and
susceptibility to myocardial infarction.
Background References:
- Man, B.L., et al.Clin Neurosci 17(10):1244-1247(2010)
- Jia, P., et al. Schizophr. Res. 122 (1-3), 38-42 (2010) :
- Le, T.M., et al. Mol. Genet. Metab. 101(1):55-61(2010)
- Fullerton, J.M., et al. Bipolar Disord 12(5):550-556(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This GCLC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-315 amino acids from the Central region of human GCLC.
NCBI Gene ID #:
2729
NCBI Official Name:
Glutamate--cysteine ligase catalytic subunit
NCBI Official Symbol:
GCLC
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
73 kDa
Protein Accession #:
P48506
Protein GI Number:
1346190
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Obesity,Signal Transduction
Swissprot #:
P48506
User NOte:
Optimal dilutions for each application to be determined by the researcher.