SRD5A2 Antibody

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ProSci
Product Code: PSI-61-971
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-61-971-400ul400ul£626.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis in mouse kidney tissue lysates (15ug/lane).This demonstrates the detected SRD5A2 protein (arrow).
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Western blot analysis in mouse kidney tissue lysates (15ug/lane).This demonstrates the detected SRD5A2 protein (arrow).

Documents

Further Information

Additional Names:
3-oxo-5-alpha-steroid 4-dehydrogenase 2, 5 alpha-SR2, SR type 2, Steroid 5-alpha-reductase 2, S5AR 2, Type II 5-alpha reductase, SRD5A2
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).
Background References:
  • Thigpen, A.E., et al. N. Engl. J. Med. 327(17):1216-1219(1992)
  • Thigpen, A.E., et al. J. Clin. Invest. 90(3):799-809(1992)
  • Labrie, F., et al. Endocrinology 131(3):1571-1573(1992)
  • Andersson, S., et al. Nature 354(6349):159-161(1991)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SRD5A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-182 amino acids from the Central region of human SRD5A2.
NCBI Gene ID #:
6716
NCBI Official Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
NCBI Official Symbol:
SRD5A2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
28 kDa
Protein Accession #:
P31213
Protein GI Number:
401056
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Obesity,Signal Transduction
Swissprot #:
P31213
User NOte:
Optimal dilutions for each application to be determined by the researcher.