PDE4A Antibody

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ProSci
Product Code: PSI-59-005
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-59-005-400ul400ul£626.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis in mouse cerebellum tissue lysates (35ug/lane).
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Western blot analysis in mouse cerebellum tissue lysates (35ug/lane).

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Further Information

Additional Names:
cAMP-specific 3',5'-cyclic phosphodiesterase 4A, DPDE2, PDE46, PDE4A, DPDE2
Application Note:
For WB starting dilution is: 1:1000
Background:
Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. PDE4A is a class IV cAMP-specific PDE (summary by Milatovich et al., 1994 [PubMed 8009369]).
Background References:
  • Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
  • Selige, J., et al. J. Cell. Physiol. 223(2):317-326(2010)
  • Bjorgo, E., et al. Mol. Cell. Biol. 30(7):1660-1672(2010)
  • Singh, D., et al. Respir. Res. 11, 26 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PDE4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human PDE4A.
NCBI Gene ID #:
5141
NCBI Official Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
NCBI Official Symbol:
PDE4A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
98 kDa
Protein Accession #:
P27815
Protein GI Number:
116242706
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Signal Transduction
Swissprot #:
P27815
User NOte:
Optimal dilutions for each application to be determined by the researcher.