TNNI3 Antibody
| Code | Size | Price |
|---|
| PSI-59-004-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Troponin I, cardiac muscle, Cardiac troponin I, TNNI3, TNNC1
Application Note:
For WB starting dilution is: 1:1000
Background:
Troponin I (TnI), along with troponin T (TnT) and troponin
C (TnC), is one of 3 subunits that form the troponin complex of the
thin filaments of striated muscle. TnI is the inhibitory subunit;
blocking actin-myosin interactions and thereby mediating striated
muscle relaxation. The TnI subfamily contains three genes:
TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and
TnI-cardiac. This gene encodes the TnI-cardiac protein and is
exclusively expressed in cardiac muscle tissues. Mutations in this
gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and
familial restrictive cardiomyopathy (RCM).
Background References:
- Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) :
- Murakami, C., et al. Leg Med (Tokyo) 12(6):280-283(2010)
- Millat, G., et al. EurMed Genet 53(5):261-267(2010)
- Di Chiara, A., et al.Cardiovasc Med (Hagerstown) 11(8):587-592(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This TNNI3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the Central region of human TNNI3.
NCBI Gene ID #:
7137
NCBI Official Name:
Troponin I, cardiac muscle
NCBI Official Symbol:
TNNI3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
24 kDa
Protein Accession #:
P19429
Protein GI Number:
136213
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Signal Transduction
Swissprot #:
P19429
User NOte:
Optimal dilutions for each application to be determined by the researcher.