NOG Antibody
| Code | Size | Price |
|---|
| PSI-59-664-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Noggin, NOG
Application Note:
For WB starting dilution is: 1:1000
Background:
The secreted polypeptide, encoded by this gene, binds and
inactivates members of the transforming growth factor-beta
(TGF-beta) superfamily signaling proteins, such as bone
morphogenetic protein-4 (BMP4). By diffusing through extracellular
matrices more efficiently than members of the TGF-beta superfamily,
this protein may have a principal role in creating morphogenic
gradients. The protein appears to have pleiotropic effect, both
early in development as well as in later stages. It was originally
isolated from Xenopus based on its ability to restore normal
dorsal-ventral body axis in embryos that had been artificially
ventralized by UV treatment. The results of the mouse knockout of
the ortholog suggest that it is involved in numerous developmental
processes, such as neural tube fusion and joint formation.
Recently, several dominant human NOG mutations in unrelated
families with proximal symphalangism (SYM1) and multiple synostoses
syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple
joint fusion as their principal feature, and map to the same region
(17q22) as this gene. All of these mutations altered evolutionarily
conserved amino acid residues. The amino acid sequence of this
human gene is highly homologous to that of Xenopus, rat and mouse.
Background References:
- Rudnik-Schoneborn, S., et al. Am. J. Med. Genet.152A (6), 1540-1544 (2010) :
- Song, K., et al. J. Biol. Chem. 285(16):12169-12180(2010)
- Mangold, E., et al. Nat. Genet. 42(1):24-26(2010)
- Gutierrez, S.J., et al. Acta Odontol Latinoam 23(1):13-19(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This NOG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-111 amino acids from the Central region of human NOG.
NCBI Gene ID #:
9241
NCBI Official Name:
Noggin
NCBI Official Symbol:
NOG
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
26 kDa
Protein Accession #:
Q13253
Protein GI Number:
15214099
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Signal Transduction
Swissprot #:
Q13253
User NOte:
Optimal dilutions for each application to be determined by the researcher.