SOST Antibody
| Code | Size | Price |
|---|
| PSI-59-168-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Sclerostin, SOST
Application Note:
For WB starting dilution is: 1:500
Background:
Sclerostin is a secreted glycoprotein with a C-terminal
cysteine knot-like (CTCK) domain and sequence similarity to the DAN
(differential screening-selected gene aberrative in neuroblastoma)
family of bone morphogenetic protein (BMP) antagonists.
Loss-of-function mutations in this gene are associated with an
autosomal-recessive disorder, sclerosteosis, which causes
progressive bone overgrowth. A deletion downstream of this gene,
which causes reduced sclerostin expression, is associated with a
milder form of the disorder called van Buchem disease. [provided by
RefSeq].
Background References:
- van Lierop, A.H., et al. Eur. J. Endocrinol. 163(5):833-837(2010)
- Liu, J.M., et al. J. Clin. Endocrinol. Metab. 95 (9), E112-E120 (2010) :
- Paternoster, L., et al. J. Clin. Endocrinol. Metab. 95(8):3940-3948(2010)
- Piters, E., et al. Hum. Mutat. 31 (7), E1526-E1543 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This SOST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-66 amino acids from the N-terminal region of human SOST.
NCBI Gene ID #:
50964
NCBI Official Name:
Sclerostin
NCBI Official Symbol:
SOST
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
24 kDa
Protein Accession #:
Q9BQB4
Protein GI Number:
20140220
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Signal Transduction
Swissprot #:
Q9BQB4
User NOte:
Optimal dilutions for each application to be determined by the researcher.