CLDN6 Antibody
| Code | Size | Price |
|---|
| PSI-55-362-200ul | 200ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Claudin-6, Skullin, CLDN6
Application Note:
For WB starting dilution is: 1:1000
Background:
Tight junctions represent one mode of cell-to-cell
adhesion in epithelial or endothelial cell sheets, forming
continuous seals around cells and serving as a physical barrier to
prevent solutes and water from passing freely through the
paracellular space. These junctions are comprised of sets of
continuous networking strands in the outwardly facing cytoplasmic
leaflet, with complementary grooves in the inwardly facing
extracytoplasmic leaflet. This gene encodes a component of tight
junction strands, which is a member of the claudin family. The
protein is an integral membrane protein and is one of the entry
cofactors for hepatitis C virus. The gene methylation may be
involved in esophageal tumorigenesis. This gene is adjacent to
another family member CLDN9 on chromosome 16.
Background References:
- Wu, Q., et al. Eur. J. Cancer Prev. 19(3):186-194(2010)
- Kleinschmidt-DeMasters, B.K., et al. Am. J. Surg. Pathol. 34(3):341-354(2010)
- Rendon-Huerta, E., et al.Gastrointest Cancer 41(1):52-59(2010)
- Wu, Q., et al. Zhonghua Yi Xue Za Zhi 90(6):407-412(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Zebrafish
Immunogen:
This CLDN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-159 amino acids from the Central region of human CLDN6.
NCBI Gene ID #:
9074
NCBI Official Name:
Claudin-6
NCBI Official Symbol:
CLDN6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
23 kDa
Protein Accession #:
P56747
Protein GI Number:
90183180
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Signal Transduction
Swissprot #:
P56747
User NOte:
Optimal dilutions for each application to be determined by the researcher.