ZBTB7B Antibody

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ProSci
Product Code: PSI-62-265
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-62-265-400ul400ul£626.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis of ZBTB7B Antibody Pab in mouse brain tissue lysates (35ug/lane)
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Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ZBTB7B antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
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Western blot analysis of ZBTB7B Antibody Pab in mouse brain tissue lysates (35ug/lane)
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ZBTB7B antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

Documents

Further Information

Additional Names:
Zinc finger and BTB domain-containing protein 7B, Krueppel-related zinc finger protein cKrox, hcKrox, T-helper-inducing POZ/Krueppel-like factor, Zinc finger and BTB domain-containing protein 15, Zinc finger protein 67 homolog, Zfp-67, Zinc finger protein 857B, Zinc finger protein Th-POK, ZBTB7B, ZBTB15, ZFP67, ZNF857B
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50
Background:
ZBTB7B is a transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. ZBTB7B is a transcriptional repressor of the collagen COL1A1 and COL1A2 genes. It may also function as a repressor of fibronectin and possibly other extracellular matrix genes.
Background References:
  • Galera,P., Proc. Natl. Acad. Sci. U.S.A. 91 (20), 9372-9376 (1994)
  • Widom,R.L., Gene 198 (1-2), 407-420 (1997)
  • Heegaard,A.M., J. Bone Miner. Res. 12 (12), 2050-2060 (1997)
  • Widom,R.L., Matrix Biol. 20 (7), 451-462 (2001)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ZBTB7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-210 amino acids from the Central region of human ZBTB7B.
NCBI Gene ID #:
51043
NCBI Official Name:
Zinc finger and BTB domain-containing protein 7B
NCBI Official Symbol:
ZBTB7B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
58 kDa
Protein Accession #:
O15156
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Immunology
Swissprot #:
O15156
User NOte:
Optimal dilutions for each application to be determined by the researcher.