MSR1 Antibody
| Code | Size | Price |
|---|
| PSI-58-866-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Macrophage scavenger receptor types I and II, Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD204, MSR1, SCARA1
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes the class A macrophage scavenger
receptors, which include three different types (1, 2, 3) generated
by alternative splicing of this gene. These receptors or isoforms
are macrophage-specific trimeric integral membrane glycoproteins
and have been implicated in many macrophage-associated
physiological and pathological processes including atherosclerosis,
Alzheimer's disease, and host defense. The isoforms type 1 and type
2 are functional receptors and are able to mediate the endocytosis
of modified low density lipoproteins (LDLs). The isoform type 3
does not internalize modified LDL (acetyl-LDL) despite having the
domain shown to mediate this function in the types 1 and 2
isoforms. It has an altered intracellular processing and is trapped
within the endoplasmic reticulum, making it unable to perform
endocytosis. The isoform type 3 can inhibit the function of
isoforms type 1 and type 2 when co-expressed, indicating a dominant
negative effect and suggesting a mechanism for regulation of
scavenger receptor activity in macrophages.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)
- Voruganti, V.S., et al. Am. J. Clin. Nutr. 91(6):1574-1583(2010)
- Nonomura, N., et al. Cancer Sci. 101(6):1570-1573(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This MSR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-364 amino acids from the C-terminal region of human MSR1.
NCBI Gene ID #:
4481
NCBI Official Name:
Macrophage scavenger receptor types I and II
NCBI Official Symbol:
MSR1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
50 kDa
Protein Accession #:
P21757
Protein GI Number:
127357
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology,Obesity
Swissprot #:
P21757
User NOte:
Optimal dilutions for each application to be determined by the researcher.