SEMA4A Antibody
| Code | Size | Price |
|---|
| PSI-58-716-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Semaphorin-4A, Semaphorin-B, Sema B, SEMA4A, SEMAB, SEMB
Application Note:
For WB starting dilution is: 1:500
Background:
This gene encodes a member of the semaphorin family of
soluble and transmembrane proteins. Semaphorins are involved in
numerous functions, including axon guidance, morphogenesis,
carcinogenesis, and immunomodulation. The encoded protein is a
single-pass type I membrane protein containing an
immunoglobulin-like C2-type domain, a PSI domain and a sema domain.
It inhibits axonal extension by providing local signals to specify
territories inaccessible for growing axons. It is an activator of
T-cell-mediated immunity and suppresses vascular endothelial growth
factor (VEGF)-mediated endothelial cell migration and proliferation
in vitro and angiogenesis in vivo. Mutations in this gene are
associated with retinal degenerative diseases including retinitis
pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10).
Multiple alternatively spliced transcript variants encoding
different isoforms have been identified.
Background References:
- Davila, S., et al. Genes Immun. 11(3):232-238(2010)
- Schmidt-Kastner, R., et al. Mol. Vis. 14, 125-135 (2008) :
- Toyofuku, T., et al. EMBO J. 26(5):1373-1384(2007)
- Abid, A., et al. J. Med. Genet. 43(4):378-381(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SEMA4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-180 amino acids from the N-terminal region of human SEMA4A.
NCBI Gene ID #:
64218
NCBI Official Name:
Semaphorin-4A
NCBI Official Symbol:
SEMA4A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
84 kDa
Protein Accession #:
Q9H3S1
Protein GI Number:
29840871
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience
Swissprot #:
Q9H3S1
User NOte:
Optimal dilutions for each application to be determined by the researcher.