PARK8 Antibody
| Code | Size | Price |
|---|
| PSI-62-661-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin, LRRK2, PARK8
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson's disease identified to date. LRRK2, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson's disease. By high-resolution recombination mapping and candidate gene sequencing in 46 families, 6 disease-segregating mutations (5 missense and 1 putative splice site mutation). It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. LRRK2 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains.
Background References:
- Shen J. Neuron. 2004. 44:575.
- Paisan-Ruiz C, et al. Neuron. 2004. 44(4):595.
- Zimprich A, et al. Neuron. 2004. 44(4):601.
- Wszolek ZK, et al. Neurology. 2004. 62(9):1619.
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PARK8(LRRK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 878-909 amino acids from human PARK8(LRRK2).
NCBI Gene ID #:
120892
NCBI Official Name:
Leucine-rich repeat serine/threonine-protein kinase 2
NCBI Official Symbol:
LRRK2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
286 kDa
Protein Accession #:
Q5S007
Protein GI Number:
294862450
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Autophagy
Swissprot #:
Q5S007
User NOte:
Optimal dilutions for each application to be determined by the researcher.