GABBR2 Antibody

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ProSci
Product Code: PSI-55-090
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-55-090-400ul400ul£626.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis in mouse cerebellum tissue lysates (35ug/lane).
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Western blot analysis in A549 cell line lysates (35ug/lane).
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Western blot analysis in mouse cerebellum tissue lysates (35ug/lane).
Western blot analysis in A549 cell line lysates (35ug/lane).

Documents

Further Information

Additional Names:
Gamma-aminobutyric acid type B receptor subunit 2, GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2, G-protein coupled receptor 51, HG20, GABBR2, GPR51, GPRC3B
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100
Background:
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.
Background References:
  • Oblak, A.L., et al. J. Neurochem. 114(5):1414-1423(2010)
  • Letra, A., et al. Am. J. Med. Genet.152A (7), 1701-1710 (2010) :
  • Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
  • Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This GABBR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 861-890 amino acids from the C-terminal region of human GABBR2.
NCBI Gene ID #:
9568
NCBI Official Name:
Gamma-aminobutyric acid type B receptor subunit 2
NCBI Official Symbol:
GABBR2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
106 kDa
Protein Accession #:
O75899
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Growth Factor
Swissprot #:
O75899
User NOte:
Optimal dilutions for each application to be determined by the researcher.