SFN Antibody

ProSci
Product Code: PSI-60-135
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-60-135-400ul400ul£626.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis in A431 cell line and mouse bladder tissue lysates (35ug/lane).

Western blot analysis in A431 cell line and mouse bladder tissue lysates (35ug/lane).

Further Information

Additional Names:
14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin, SFN, HME1
Application Note:
For WB starting dilution is: 1:1000
Background:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
Background References:
  • Ren, H.Z., et al. Dig. Dis. Sci. 55(9):2552-2560(2010)
  • Liu, Y., et al. Brain Res. 1336, 98-102 (2010) :
  • Pei, H.P., et al. Zhonghua Wei Chang Wai Ke Za Zhi 13(3):213-215(2010)
  • Syrjanen, S., et al. Am. J. Clin. Pathol. 133(2):232-240(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This SFN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-149 amino acids from the Central region of human SFN.
NCBI Gene ID #:
2810
NCBI Official Name:
14-3-3 protein sigma
NCBI Official Symbol:
SFN
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
28 kDa
Protein Accession #:
P31947
Protein GI Number:
398953
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
P31947
User NOte:
Optimal dilutions for each application to be determined by the researcher.