L1CAM Antibody
| Code | Size | Price |
|---|
| PSI-58-338-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Neural cell adhesion molecule L1, N-CAM-L1, NCAM-L1, CD171, L1CAM, CAML1, MIC5
Application Note:
For WB starting dilution is: 1:1000
Background:
L1CAM is an axonal glycoprotein
belonging to the immunoglobulin supergene family. The ectodomain,
consisting of several immunoglobulin-like domains and
fibronectin-like repeats (type III), is linked via a single
transmembrane sequence to a conserved cytoplasmic domain. This cell
adhesion molecule plays an important role in nervous system
development, including neuronal migration and differentiation.
Mutations in the gene cause three X-linked neurological syndromes
known by the acronym CRASH (corpus callosum hypoplasia,
retardation, aphasia, spastic paraplegia and hydrocephalus).
Alternative splicing of a neuron-specific exon is thought to be
functionally relevant.
Background References:
- Schafer, M.K., et al. FEBS Lett. 584(21):4475-4480(2010)
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Bertolin, C., et al. J. Neurol. Sci. 294 (1-2), 124-126 (2010) :
- Schafer, M.K., et al. Cell. Mol. Life Sci. 67(14):2425-2437(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This L1CAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1154-1182 amino acids from the C-terminal region of human L1CAM.
NCBI Gene ID #:
3897
NCBI Official Name:
Neural cell adhesion molecule L1
NCBI Official Symbol:
L1CAM
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
140 kDa
Protein Accession #:
P32004
Protein GI Number:
1705571
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
P32004
User NOte:
Optimal dilutions for each application to be determined by the researcher.