PMCH Antibody
| Code | Size | Price |
|---|
| PSI-61-963-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Pro-MCH, Neuropeptide-glycine-glutamic acid, NGE, Neuropeptide G-E, Neuropeptide-glutamic acid-isoleucine, NEI, Neuropeptide E-I, Melanin-concentrating hormone, MCH, PMCH, MCH
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
Background:
The melanin-concentrating hormone (MCH) is a cyclic
neuropeptide isolated initially from salmon pituitary gland and
later from rat hypothalamus (summarized by Nahon et al., 1992
[PubMed 1572663]). In mammals, MCH perikarya are confined largely
to the lateral hypothalamus and zona incerta area with extensive
neuronal projections throughout the brain, including the
neurohypophysis. The anatomic distribution suggests a
neurotransmitter or neuromodulator role for MCH in a broad array of
neuronal functions directed toward the regulation of goal-directed
behavior, such as food intake, and general arousal. MCH and 2 other
putative neuropeptides, NEI and NGE, are encoded by the same
precursor and appear colocalized in nerve cells and in many
instances within the projections. The precursor is designated
pro-melanin-concentrating hormone (PMCH).
Background References:
- Kim, J.J., et al. J. Hum. Genet. 55(1):27-31(2010)
- Gratacos, M., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :
- Aziz, A., et al. Brain Pathol. 18(4):474-483(2008)
- Kokkotou, E., et al. Proc. Natl. Acad. Sci. U.S.A. 105(30):10613-10618(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PMCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-122 amino acids from the Central region of human PMCH.
NCBI Gene ID #:
5367
NCBI Official Name:
Pro-MCH
NCBI Official Symbol:
PMCH
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
19 kDa
Protein Accession #:
P20382
Protein GI Number:
229462960
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
P20382
User NOte:
Optimal dilutions for each application to be determined by the researcher.