GHSR Antibody

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ProSci
Product Code: PSI-56-090
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-56-090-400ul400ul£626.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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GHSR Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human uterus tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
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Western blot analysis in NCI-H292 cell line and mouse bladder tissue lysates (35ug/lane).
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GHSR Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human uterus tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in NCI-H292 cell line and mouse bladder tissue lysates (35ug/lane).

Documents

Further Information

Additional Names:
Growth hormone secretagogue receptor type 1, GHS-R, GH-releasing peptide receptor, GHRP, Ghrelin receptor, GHSR
Application Note:
For IHC-P starting dilution is: 1:50~100

For WB starting dilution is: 1:1000
Background:
This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.
Background References:
  • Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
  • Landgren, S., et al. Alcohol. Clin. Exp. Res. 34(9):1519-1524(2010)
  • Aghajanova, L., et al. Reprod Sci 17(9):823-832(2010)
  • Pinheiro, A.P., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Pig, Rabbit
Immunogen:
This GHSR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326-357 amino acids from the C-terminal region of human GHSR.
NCBI Gene ID #:
2693
NCBI Official Name:
Growth hormone secretagogue receptor type 1
NCBI Official Symbol:
GHSR
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
41 kDa
Protein Accession #:
Q92847
Protein GI Number:
2494998
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Neuroscience,Growth Factor
Swissprot #:
Q92847
User NOte:
Optimal dilutions for each application to be determined by the researcher.