ProSci

Insulin Receptor R Antibody

Product Code:
 
PSI-63-105
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western Blot at 1:2000 dilution + mouse brain lysate Lysates/proteins at 20 ug per lane.
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Western Blot at 1:2000 dilution Lane 1: 293T/17 whole cell lysate Lane 2: Hela whole cell lysate Lane 3: MCF-7 whole cell lysate Lane 4: PC-12 whole cell lysate Lane 5: SH-SY5Y whole cell lysate Lysates/proteins at 20 ug per lane.
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Formalin-fixed and paraffin-embedded human testis tissue reacted with INSRR antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
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Western Blot at 1:2000 dilution + mouse brain lysate Lysates/proteins at 20 ug per lane.
Western Blot at 1:2000 dilution Lane 1: 293T/17 whole cell lysate Lane 2: Hela whole cell lysate Lane 3: MCF-7 whole cell lysate Lane 4: PC-12 whole cell lysate Lane 5: SH-SY5Y whole cell lysate Lysates/proteins at 20 ug per lane.
Formalin-fixed and paraffin-embedded human testis tissue reacted with INSRR antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

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PSI-63-105-400ul400ul£626.00
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Further Information

Additional Names:
Insulin receptor-related protein, IRR, IR-related receptor, Insulin receptor-related protein alpha chain, Insulin receptor-related protein beta chain, INSRR, IRR
Application Note:
For WB starting dilution is: 1:2000

For IHC-P starting dilution is: 1:10~50
Background:
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
Background References:
  • Shier, P., et al., J. Biol. Chem. 264(25):14605-14608 (1989).
  • Whitmore, T.E., et al., Cytogenet. Cell Genet. 87 (1-2), 93-94 (1999).
  • Hanze, J., et al., Horm. Metab. Res. 31 (2-3), 77-79 (1999).
  • Shier, P., et al., Cytogenet. Cell Genet. 54 (1-2), 80-81 (1990).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This Insulin Receptor R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-47 amino acids from the N-terminal region of human Insulin Receptor R.
NCBI Gene ID #:
3645
NCBI Official Name:
Insulin receptor-related protein
NCBI Official Symbol:
INSRR
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
144 kDa
Protein Accession #:
P14616
Protein GI Number:
12644000
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Neuroscience,Signal Transduction
Swissprot #:
P14616
User NOte:
Optimal dilutions for each application to be determined by the researcher.