DUSP12 Antibody
| Code | Size | Price |
|---|
| PSI-58-792-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Dual specificity protein phosphatase 12, Dual specificity tyrosine phosphatase YVH1, DUSP12
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a member of the dual
specificity protein phosphatase subfamily. These phosphatases
inactivate their target kinases by dephosphorylating both the
phosphoserine/threonine and phosphotyrosine residues. They
negatively regulate members of the mitogen-activated protein (MAP)
kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated
with cellular proliferation and differentiation. Different members
of the family of dual specificity phosphatases show distinct
substrate specificities for various MAP kinases, different tissue
distribution and subcellular localization, and different modes of
inducibility of their expression by extracellular stimuli. This
gene product is the human ortholog of the Saccharomyces cerevisiae
YVH1 protein tyrosine phosphatase. It is localized predominantly in
the nucleus, and is novel in that it contains, and is regulated by
a zinc finger domain.
Background References:
- Biernacki, M.A., et al. Cancer Res. 70(3):906-915(2010)
- Bonham, C.A., et al. J. Biol. Chem. 284(34):22853-22864(2009)
- Sharda, P.R., et al. Biochem. J. 418(2):391-401(2009)
- Gao, F., et al. Zhonghua Yi Xue Za Zhi 88(32):2250-2253(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This DUSP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-191 amino acids from the Central region of human DUSP12.
NCBI Gene ID #:
11266
NCBI Official Name:
Dual specificity protein phosphatase 12
NCBI Official Symbol:
DUSP12
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
38 kDa
Protein Accession #:
Q9UNI6
Protein GI Number:
9973073
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q9UNI6
User NOte:
Optimal dilutions for each application to be determined by the researcher.