PRL1 Antibody
| Code | Size | Price |
|---|
| PSI-63-471-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Protein tyrosine phosphatase type IVA 1, PTP(CAAXI), Protein-tyrosine phosphatase 4a1, Protein-tyrosine phosphatase of regenerating liver 1, PRL-1, PTP4A1, PRL1, PTPCAAX1
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells.PRL phosphatases increase cell proliferation by stimulating progression from G1 into S phase. PRL-1 function is regulated in a cell cycle-dependent manner and implicate PRL-1 in regulating progression through mitosis, possibly by modulating spindle dynamics.
Background References:
- Jeong,D.G., et al. J. Mol. Biol. 345 (2), 401-413 (2005)
- Werner,S.R., et al. Cancer Lett. 202 (2), 201-211 (2003)
- Wang,J., et al. J. Biol. Chem. 277 (48), 46659-46668 (2002)
- Nicolas,G., et al. Mol. Cell. Biol. 22 (10), 3527-3536 (2002)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PRL1 antibody is generated from rabbits immunized with a recombinant protein encoding full length of human PRL1.
NCBI Gene ID #:
7803
NCBI Official Name:
Protein tyrosine phosphatase type IVA 1
NCBI Official Symbol:
PTP4A1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
20 kDa
Protein Accession #:
Q93096
Protein GI Number:
68566217
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Signal Transduction
Swissprot #:
Q93096
User NOte:
Optimal dilutions for each application to be determined by the researcher.