TEF Antibody
| Code | Size | Price |
|---|
| PSI-60-382-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Thyrotroph embryonic factor, TEF, KIAA1655
Application Note:
For WB starting dilution is: 1:1000
Background:
Thyrotroph embryonic factor (TEF), a transcription factor,
is a member of the PAR (proline and acidic amino acid-rich)
subfamily of basic region/leucine zipper (bZIP) transcription
factors. It is expressed in a broad range of cells and tissues in
adult animals, however, during embryonic development, TEF
expression appears to be restricted to the developing anterior
pituitary gland, coincident with the appearance of
thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to,
and transactivate the TSHB promoter. It shows homology (in the
functional domains) with other members of the PAR-bZIP subfamily of
transcription factors, which include albumin D box-binding protein
(DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin
gene-binding protein (VBP); VBP is considered the chicken homologue
of TEF. Different members of the subfamily can readily form
heterodimers, and share DNA-binding, and transcriptional regulatory
properties. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq].
Background References:
- Kripke, D.F., et al. Psychiatry Investig 7(1):36-42(2010)
- Inukai, T., et al. Blood 105(11):4437-4444(2005)
- Collins, J.E., et al. Genome Biol.(10), R84 (2004) :
- Newman, J.R., et al. Science 300(5628):2097-2101(2003)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Chicken, Rat
Immunogen:
This TEF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 213-240 amino acids from the C-terminal region of human TEF.
NCBI Gene ID #:
7008
NCBI Official Name:
Thyrotroph embryonic factor
NCBI Official Symbol:
TEF
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
33 kDa
Protein Accession #:
Q10587
Protein GI Number:
51338730
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q10587
User NOte:
Optimal dilutions for each application to be determined by the researcher.