MUTED Antibody

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ProSci
Product Code: PSI-55-052
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-55-052-400ul400ul£626.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis in MDA-MB435 cell line lysates (15ug/lane).This demonstrates the detected MUTED protein (arrow).
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Western blot analysis in mouse bladder tissue lysates (15ug/lane).This demonstrates the detected MUTED protein (arrow).
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Western blot analysis in MDA-MB435 cell line lysates (15ug/lane).This demonstrates the detected MUTED protein (arrow).
Western blot analysis in mouse bladder tissue lysates (15ug/lane).This demonstrates the detected MUTED protein (arrow).

Documents

Further Information

Additional Names:
Biogenesis of lysosome-related organelles complex 1 subunit 5, BLOC-1 subunit 5, Protein Muted homolog, BLOC1S5, MUTED
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100
Background:
This gene encodes a component of BLOC-1 (biogenesis of lysosome-related organelles complex 1). Components of this complex are involved in the biogenesis of organelles such as melanosomes and platelet-dense granules. A mouse model for Hermansky-Pudlak Syndrome is mutated in the murine version of this gene. Alternative splicing results in multiple transcript variants. Read-through transcription exists between this gene and the upstream EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1) gene, as well as with the downstream TXNDC5 (thioredoxin domain containing 5) gene.
Background References:
  • Morris, D.W., et al. Biol. Psychiatry 63(1):24-31(2008)
  • Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
  • Starcevic, M., et al. J. Biol. Chem. 279(27):28393-28401(2004)
  • Li, W., et al. Nat. Genet. 35(1):84-89(2003)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Pig
Immunogen:
This MUTED antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-68 amino acids from the Central region of human MUTED.
NCBI Gene ID #:
63915
NCBI Official Name:
Biogenesis of lysosome-related organelles complex 1 subunit 5
NCBI Official Symbol:
BLOC1S5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
22 kDa
Protein Accession #:
Q8TDH9
Protein GI Number:
34582369
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q8TDH9
User NOte:
Optimal dilutions for each application to be determined by the researcher.