PELP1 Antibody

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ProSci
Product Code: PSI-56-089
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-56-089-400ul400ul£626.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Antibody staining PELP1 in human colon tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections).
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Antibody staining PELP1 in human colon tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections).
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Western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the PELP1 antibody detected the PELP1 protein (arrow).
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Antibody staining PELP1 in human colon tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections).
Antibody staining PELP1 in human colon tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections).
Western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the PELP1 antibody detected the PELP1 protein (arrow).

Documents

Further Information

Additional Names:
Proline-, glutamic acid- and leucine-rich protein 1, Modulator of non-genomic activity of estrogen receptor, Transcription factor HMX3, PELP1, HMX3, MNAR
Application Note:
For IHC-P starting dilution is: 1:25

For WB starting dilution is: 1:1000
Background:
PELP1 is a coactivator of estrogen receptor (see ESR1; MIM 133430)-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (Choi et al., 2004 [PubMed 15456770]).
Background References:
  • Nair, S.S., et al. EMBO Rep. 11(6):438-444(2010)
  • Habashy, H.O., et al. Breast Cancer Res. Treat. 120(3):603-612(2010)
  • Vadlamudi, R.K., et al. J. Steroid Biochem. Mol. Biol. 118 (4-5), 211-218 (2010) :
  • Tzelepi, V., et al. Virchows Arch. 454(1):41-53(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This PELP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 744-771 amino acids from the Central region of human PELP1.
NCBI Gene ID #:
27043
NCBI Official Name:
Proline-, glutamic acid- and leucine-rich protein 1
NCBI Official Symbol:
PELP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
120 kDa
Protein Accession #:
Q8IZL8
Protein GI Number:
115502553
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q8IZL8
User NOte:
Optimal dilutions for each application to be determined by the researcher.