HSC70 Interacting Protein HIP Antibody

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ProSci
Product Code: PSI-62-195
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-62-195-400ul400ul£626.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with ST13 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
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Western blot analysis of anti-ST13 Antibody pre-incubated with and without blocking peptide (BP6247a) in A2058 cell line lysate.
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Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with ST13 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Western blot analysis of anti-ST13 Antibody pre-incubated with and without blocking peptide (BP6247a) in A2058 cell line lysate.

Documents

Further Information

Additional Names:
Hsc70-interacting protein, Hip, Aging-associated protein 2, Progesterone receptor-associated p48 protein, Protein FAM10A1, Putative tumor suppressor ST13, Renal carcinoma antigen NY-REN-33, Suppression of tumorigenicity 13 protein, ST13, AAG2, FAM10A1, HIP, SNC6
Application Note:
For IHC-P starting dilution is: 1:10~50

For WB starting dilution is: 1:1000
Background:
ST13 is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this protein is reported to be downregulated in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor.
Background References:
  • Rajapandi, T., et al., J. Biol. Chem. 275(29):22597-22604 (2000).
  • Morishima, Y., et al., J. Biol. Chem. 275(10):6894-6900 (2000).
  • Chen, S., et al., J. Biol. Chem. 273(52):35194-35200 (1998).
  • Johnson, B.D., et al., J. Biol. Chem. 273(6):3679-3686 (1998).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This HSC70 Interacting Protein HIP (ST13) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-80 amino acids from human HSC70 Interacting Protein HIP (ST13).
NCBI Gene ID #:
6767
NCBI Official Name:
Hsc70-interacting protein
NCBI Official Symbol:
ST13
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
41 kDa
Protein Accession #:
P50502
Protein GI Number:
6686278
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Signal Transduction
Swissprot #:
P50502
User NOte:
Optimal dilutions for each application to be determined by the researcher.