TGFBR2 Antibody
| Code | Size | Price |
|---|
| PSI-56-081-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
TGF-beta receptor type-2, TGFR-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TbetaR-II, TGFBR2
Application Note:
For IHC-P starting dilution is: 1:25
For WB starting dilution is: 1:1000
For WB starting dilution is: 1:1000
Background:
This gene encodes a member of the Ser/Thr protein kinase
family and the TGFB receptor subfamily. The encoded protein is a
transmembrane protein that has a protein kinase domain, forms a
heterodimeric complex with another receptor protein, and binds
TGF-beta. This receptor/ligand complex phosphorylates proteins,
which then enter the nucleus and regulate the transcription of a
subset of genes related to cell proliferation. Mutations in this
gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic
Aneurysm Syndrome, and the development of various types of tumors.
Alternatively spliced transcript variants encoding different
isoforms have been characterized.
Background References:
- Inamoto, S., et al. Cardiovasc. Res. 88(3):520-529(2010)
- Bianchini, G., et al. J. Clin. Oncol. 28(28):4316-4323(2010)
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Kim, J.N., et al. Toxicology 275 (1-3), 29-35 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This TGFBR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-40 amino acids from the N-terminal region of human TGFBR2.
NCBI Gene ID #:
7048
NCBI Official Name:
TGF-beta receptor type-2
NCBI Official Symbol:
TGFBR2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
65 kDa
Protein Accession #:
P37173
Protein GI Number:
116242818
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
P37173
User NOte:
Optimal dilutions for each application to be determined by the researcher.