DVL1 Antibody
| Code | Size | Price |
|---|
| PSI-56-349-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Segment polarity protein dishevelled homolog DVL-1, Dishevelled-1, DSH homolog 1, DVL1
Application Note:
For IF starting dilution is: 1:25
For IHC-P starting dilution is: 1:25
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:25
For WB starting dilution is: 1:1000
Background:
DVL1, the human homolog of the Drosophila dishevelled gene
(dsh) encodes a cytoplasmic phosphoprotein that regulates cell
proliferation, acting as a transducer molecule for developmental
processes, including segmentation and neuroblast specification.
DVL1 is a candidate gene for neuroblastomatous transformation. The
Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A
have been mapped to the same region as DVL1. The phenotypes of
these diseases may be consistent with defects which might be
expected from aberrant expression of a DVL gene during development.
Background References:
- Metcalfe, C., et al. J. Cell. Sci. 123 (PT 9), 1588-1599 (2010) :
- Hu, T., et al. J. Biol. Chem. 285(18):13561-13568(2010)
- Varelas, X., et al. Dev. Cell 18(4):579-591(2010)
- Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This DVL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 442-470 amino acids from the Central region of human DVL1.
NCBI Gene ID #:
1855
NCBI Official Name:
Segment polarity protein dishevelled homolog DVL-1
NCBI Official Symbol:
DVL1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
75 kDa
Protein Accession #:
O14640
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
O14640
User NOte:
Optimal dilutions for each application to be determined by the researcher.