TEAD2 Antibody
| Code | Size | Price |
|---|
| PSI-57-616-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Transcriptional enhancer factor TEF-4, TEA domain family member 2, TEAD-2, TEAD2, TEF4
Application Note:
For WB starting dilution is: 1:1000
Background:
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Tian, W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7293-7298(2010)
- Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
- Zhang, H., et al. J. Biol. Chem. 284(20):13355-13362(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This TEAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-295 amino acids from the Central region of human TEAD2.
NCBI Gene ID #:
8463
NCBI Official Name:
Transcriptional enhancer factor TEF-4
NCBI Official Symbol:
TEAD2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
49 kDa
Protein Accession #:
Q15562
Protein GI Number:
21264529
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q15562
User NOte:
Optimal dilutions for each application to be determined by the researcher.