RPL22 Antibody
| Code | Size | Price |
|---|
| PSI-60-748-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
60S ribosomal protein L22, EBER-associated protein, EAP, Epstein-Barr virus small RNA-associated protein, Heparin-binding protein HBp15, RPL22
Application Note:
For WB starting dilution is: 1:2000
Background:
Ribosomes, the organelles that catalyze protein synthesis,
consist of a small 40S subunit and a large 60S subunit. Together
these subunits are composed of 4 RNA species and approximately 80
structurally distinct proteins. This gene encodes a cytoplasmic
ribosomal protein that is a component of the 60S subunit. The
protein belongs to the L22E family of ribosomal proteins. Its
initiating methionine residue is post-translationally removed. The
protein can bind specifically to Epstein-Barr virus-encoded RNAs
(EBERs) 1 and 2. The mouse protein has been shown to be capable of
binding to heparin. Transcript variants utilizing alternative polyA
signals exist. As is typical for genes encoding ribosomal proteins,
there are multiple processed pseudogenes of this gene dispersed
through the genome. It was previously thought that this gene mapped
to 3q26 and that it was fused to the acute myeloid leukemia 1
(AML1) gene located at 21q22 in some therapy-related
myelodysplastic syndrome patients with 3;21 translocations;
however, these fusions actually involve a ribosomal protein L22
pseudogene located at 3q26, and this gene actually maps to
1p36.3-p36.2.
Background References:
- Houmani, J.L., et al. J. Virol. 83(19):9844-9853(2009)
- Maggi, L.B. Jr., et al. Mol. Cell. Biol. 28(23):7050-7065(2008)
- Fok, V., et al. RNA 12(5):872-882(2006)
- Nakao, K., et al. Otolaryngol Head Neck Surg 134(4):639-645(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Chicken, Monkey, Pig, Rat, Xenopus
Immunogen:
This RPL22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-121 amino acids from the C-terminal region of human RPL22.
NCBI Gene ID #:
6146
NCBI Official Name:
60S ribosomal protein L22
NCBI Official Symbol:
RPL22
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
15 kDa
Protein Accession #:
P35268
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P35268
User NOte:
Optimal dilutions for each application to be determined by the researcher.