IKZF3 Antibody
| Code | Size | Price |
|---|
| PSI-61-999-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Zinc finger protein Aiolos, Ikaros family zinc finger protein 3, IKZF3, ZNFN1A3
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a member of the Ikaros family of
zinc-finger proteins. Three members of this protein family (Ikaros,
Aiolos and Helios) are hematopoietic-specific transcription factors
involved in the regulation of lymphocyte development. This gene
product is a transcription factor that is important in the
regulation of B lymphocyte proliferation and differentiation. Both
Ikaros and Aiolos can participate in chromatin remodeling.
Regulation of gene expression in B lymphocytes by Aiolos is complex
as it appears to require the sequential formation of Ikaros
homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At
least six alternative transcripts encoding different isoforms have
been described.
Background References:
- Billot, K., et al. Leuk. Res. 34(3):289-293(2010)
- Hirschfield, G.M., et al. N. Engl. J. Med. 360(24):2544-2555(2009)
- Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):255-259(2009)
- Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This IKZF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-103 amino acids from the Central region of human IKZF3.
NCBI Gene ID #:
22806
NCBI Official Name:
Zinc finger protein Aiolos
NCBI Official Symbol:
IKZF3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
58 kDa
Protein Accession #:
Q9UKT9
Protein GI Number:
212276437
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9UKT9
User NOte:
Optimal dilutions for each application to be determined by the researcher.