MXI1 Antibody
| Code | Size | Price |
|---|
| PSI-58-142-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Max-interacting protein 1, Max interactor 1, Class C basic helix-loop-helix protein 11, bHLHc11, MXI1, BHLHC11
Application Note:
For WB starting dilution is: 1:1000
Background:
Expression of the c-myc gene, which produces an oncogenic
transcription factor, is tightly regulated in normal cells but is
frequently deregulated in human cancers. The protein encoded by
this gene is a transcriptional repressor thought to negatively
regulate MYC function, and is therefore a potential tumor
suppressor. This protein inhibits the transcriptional activity of
MYC by competing for MAX, another basic helix-loop-helix protein
that binds to MYC and is required for its function. Defects in this
gene are frequently found in patients with prostate tumors. Three
alternatively spliced transcripts encoding different isoforms have
been described. Additional alternatively spliced transcripts may
exist but the products of these transcripts have not been verified
experimentally.
Background References:
- Lofstedt, T., et al. Exp. Cell Res. 315(11):1924-1936(2009)
- Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009)
- Tsao, C.C., et al. Cancer Biol. Ther. 7(10):1619-1627(2008)
- Suo, X.H., et al. Zhonghua Xue Ye Xue Za Zhi 28(11):745-749(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This MXI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-82 amino acids from the Central region of human MXI1.
NCBI Gene ID #:
4601
NCBI Official Name:
Max-interacting protein 1
NCBI Official Symbol:
MXI1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
26 kDa
Protein Accession #:
P50539
Protein GI Number:
116242666
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P50539
User NOte:
Optimal dilutions for each application to be determined by the researcher.