TOP3B Antibody
| Code | Size | Price |
|---|
| PSI-58-713-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
DNA topoisomerase 3-beta-1, DNA topoisomerase III beta-1, TOP3B, TOP3B1
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a DNA topoisomerase, an enzyme that
controls and alters the topologic states of DNA during
transcription. This enzyme catalyzes the transient breaking and
rejoining of a single strand of DNA which allows the strands to
pass through one another, thus relaxing the supercoils and altering
the topology of DNA. The enzyme interacts with DNA helicase SGS1
and plays a role in DNA recombination, cellular aging and
maintenance of genome stability. Alternative splicing of the
C-terminus of this gene results in three transcript variants which
have distinct tissue specificity; however, not all variants have
been fully described.
Background References:
- Oliveira-Costa, J.P., et al. Hum. Pathol. 41(11):1624-1630(2010)
- Lesch, K.P., et al.Neural Transm 115(11):1573-1585(2008)
- Cho, Y.H., et al. Biochim. Biophys. Acta 1679(3):272-278(2004)
- Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This TOP3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 826-854 amino acids from the C-terminal region of human TOP3B.
NCBI Gene ID #:
8940
NCBI Official Name:
DNA topoisomerase 3-beta-1
NCBI Official Symbol:
TOP3B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
97 kDa
Protein Accession #:
O95985
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
O95985
User NOte:
Optimal dilutions for each application to be determined by the researcher.