E2F2 Antibody
| Code | Size | Price |
|---|
| PSI-55-208-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Transcription factor E2F2, E2F-2, E2F2
Application Note:
For WB starting dilution is: 1:1000
Background:
E2F2 is a member of the E2F
family of transcription factors. The E2F family plays a crucial
role in the control of cell cycle and action of tumor suppressor
proteins and is also a target of the transforming proteins of small
DNA tumor viruses. The E2F proteins contain several evolutionally
conserved domains found in most members of the family. These
domains include a DNA binding domain, a dimerization domain which
determines interaction with the differentiation regulated
transcription factor proteins (DP), a transactivation domain
enriched in acidic amino acids, and a tumor suppressor protein
association domain which is embedded within the transactivation
domain. This protein and another 2 members, E2F1 and E2F3, have an
additional cyclin binding domain. This protein binds specifically
to retinoblastoma protein pRB in a cell-cycle dependent manner, and
it exhibits overall 46% amino acid identity to E2F1. [provided by
RefSeq].
Background References:
- Revenko, A.S., et al. Mol. Cell. Biol. 30(22):5260-5272(2010)
- Hayami, S., et al. Mol. Cancer 9, 59 (2010) :
- Chen, J., et al. Cancer Causes Control 20(9):1769-1777(2009)
- Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This E2F2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-286 amino acids from the Central region of human E2F2.
NCBI Gene ID #:
1870
NCBI Official Name:
Transcription factor E2F2
NCBI Official Symbol:
E2F2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
48 kDa
Protein Accession #:
Q14209
Protein GI Number:
2494228
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q14209
User NOte:
Optimal dilutions for each application to be determined by the researcher.