NSUN2 Antibody
| Code | Size | Price |
|---|
| PSI-55-438-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
tRNA (cytosine(34)-C(5))-methyltransferase, Myc-induced SUN domain-containing protein, Misu, NOL1/NOP2/Sun domain family member 2, Substrate of AIM1/Aurora kinase B, tRNA (cytosine-5-)-methyltransferase, tRNA methyltransferase 4 homolog, hTrm4, NSUN2, SAKI, TRM4
Application Note:
For WB starting dilution is: 1:1000
Background:
Maturation of cytoplasmic tRNAs includes splicing of
introns, which are located 1 nucleotide 3-prime from the anticodon
in all intron-containing tRNA genes. In tRNA-leu(CAA), the first
position of the anticodon, C34, is converted to 5-methylcytosine, a
modification necessary to stabilize the anticodon-codon pairing and
correctly translate the mRNA. NSUN2 encodes a methyltransferase
that catalyzes the intron-dependent formation of 5-methylcytosine
at C34 of tRNA-leu(CAA) (Brzezicha et al., 2006 [PubMed
17071714]).
Background References:
- Bailey, S.D., et al. Diabetes Care (2010) In press :
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Frye, M., et al. Cancer Lett. 289(1):71-80(2010)
- Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This NSUN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 423-451 amino acids from the Central region of human NSUN2.
NCBI Gene ID #:
54888
NCBI Official Name:
tRNA (cytosine(34)-C(5))-methyltransferase
NCBI Official Symbol:
NSUN2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
86 kDa
Protein Accession #:
Q08J23
Protein GI Number:
148887180
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q08J23
User NOte:
Optimal dilutions for each application to be determined by the researcher.