PCBP1 Antibody
| Code | Size | Price |
|---|
| PSI-60-150-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Poly(rC)-binding protein 1, Alpha-CP1, Heterogeneous nuclear ribonucleoprotein E1, hnRNP E1, Nucleic acid-binding protein SUB23, PCBP1
Application Note:
For WB starting dilution is: 1:1000
Background:
This intronless gene is thought to have been generated by
retrotransposition of a fully processed PCBP-2 mRNA. This gene and
PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have
arisen as a result of duplication events of entire genes. The
protein encoded by this gene appears to be multifunctional. It
along with PCBP-2 and hnRNPK corresponds to the major cellular
poly(rC)-binding protein. It contains three K-homologous (KH)
domains which may be involved in RNA binding. This encoded protein
together with PCBP-2 also functions as translational coactivators
of poliovirus RNA via a sequence-specific interaction with
stem-loop IV of the IRES and promote poliovirus RNA replication by
binding to its 5'-terminal cloverleaf structure. It has also been
implicated in translational control of the 15-lipoxygenase mRNA,
human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA.
The encoded protein is also suggested to play a part in formation
of a sequence-specific alpha-globin mRNP complex which is
associated with alpha-globin mRNA stability.
Background References:
- Cloke, B., et al. Endocrinology 151(8):3954-3964(2010)
- Wang, H., et al. Cancer Cell 18(1):52-62(2010)
- Zhang, T., et al. Mol. Cancer 9, 72 (2010) :
- Waggoner, S.A., et al. J. Biol. Chem. 284(14):9039-9049(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Rabbit
Immunogen:
This PCBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-217 amino acids from the Central region of human PCBP1.
NCBI Gene ID #:
5093
NCBI Official Name:
Poly(rC)-binding protein 1
NCBI Official Symbol:
PCBP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
37 kDa
Protein Accession #:
Q15365
Protein GI Number:
42560548
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q15365
User NOte:
Optimal dilutions for each application to be determined by the researcher.