TDP1 Antibody
| Code | Size | Price |
|---|
| PSI-59-353-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Tyrosyl-DNA phosphodiesterase 1, Tyr-DNA phosphodiesterase 1, 314-, TDP1
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is involved in repairing
stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis
of the phosphodiester bond between the tyrosine residue of
topoisomerase I and the 3-prime phosphate of DNA. This protein may
also remove glycolate from single-stranded DNA containing 3-prime
phosphoglycolate, suggesting a role in repair of free-radical
mediated DNA double-strand breaks. This gene is a member of the
phospholipase D family and contains two PLD phosphodiesterase
domains. Mutations in this gene are associated with the disease
spinocerebellar ataxia with axonal neuropathy (SCAN1). While
several transcript variants may exist for this gene, the
full-length natures of only two have been described to date. These
two represent the major variants of this gene and encode the same
isoform.
Background References:
- Dexheimer, T.S., et al. Nucleic Acids Res. 38(7):2444-2452(2010)
- Chiang, S.C., et al. Cell Cycle 9(3):588-595(2010)
- Das, B.B., et al. EMBO J. 28(23):3667-3680(2009)
- Zhou, T., et al. DNA Repair (Amst.) 8(8):901-911(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This TDP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-239 amino acids from the Central region of human TDP1.
NCBI Gene ID #:
55775
NCBI Official Name:
Tyrosyl-DNA phosphodiesterase 1
NCBI Official Symbol:
TDP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
68 kDa
Protein Accession #:
Q9NUW8
Protein GI Number:
37999797
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9NUW8
User NOte:
Optimal dilutions for each application to be determined by the researcher.