F13B Antibody
| Code | Size | Price |
|---|
| PSI-60-904-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Coagulation factor XIII B chain, Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain, F13B
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes coagulation factor XIII B subunit.
Coagulation factor XIII is the last zymogen to become activated in
the blood coagulation cascade. Plasma factor XIII is a
heterotetramer composed of 2 A subunits and 2 B subunits. The A
subunits have catalytic function, and the B subunits do not have
enzymatic activity and may serve as a plasma carrier molecules.
Platelet factor XIII is comprised only of 2 A subunits, which are
identical to those of plasma origin. Upon activation by the
cleavage of the activation peptide by thrombin and in the presence
of calcium ion, the plasma factor XIII dissociates its B subunits
and yields the same active enzyme, factor XIIIa, as platelet factor
XIII. This enzyme acts as a transglutaminase to catalyze the
formation of gamma-glutamyl-epsilon-lysine crosslinking between
fibrin molecules, thus stabilizing the fibrin clot. Factor XIII
deficiency is classified into two categories: type I deficiency,
characterized by the lack of both the A and B subunits; and type II
deficiency, characterized by the lack of the A subunit alone.
These defects can result in a lifelong bleeding tendency, defective
wound healing, and habitual abortion.
Background References:
- Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)
- Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This F13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-179 amino acids from the N-terminal region of human F13B.
NCBI Gene ID #:
2165
NCBI Official Name:
Coagulation factor XIII B chain
NCBI Official Symbol:
F13B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
76 kDa
Protein Accession #:
P05160
Protein GI Number:
145559473
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P05160
User NOte:
Optimal dilutions for each application to be determined by the researcher.