ERCC8 Antibody
| Code | Size | Price |
|---|
| PSI-55-526-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
DNA excision repair protein ERCC-8, Cockayne syndrome WD repeat protein CSA, ERCC8, CKN1, CSA
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For IHC-P starting dilution is: 1:50~100
Background:
This gene encodes a WD repeat protein, which interacts
with Cockayne syndrome type B (CSB) protein and with p44 protein, a
subunit of the RNA polymerase II transcription factor IIH.
Mutations in this gene have been identified in patients with
hereditary disease Cockayne syndrome (CS). CS cells are abnormally
sensitive to ultraviolet radiation and are defective in the repair
of transcriptionally active genes.
Background References:
- Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)
- Guillem, V.M., et al. Am. J. Hematol. 85(7):482-486(2010)
- Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press :
- Kamenisch, Y., et al. J. Exp. Med. 207(2):379-390(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ERCC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-238 amino acids from the Central region of human ERCC8.
NCBI Gene ID #:
1161
NCBI Official Name:
DNA excision repair protein ERCC-8
NCBI Official Symbol:
ERCC8
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
44 kDa
Protein Accession #:
Q13216
Protein GI Number:
3121917
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q13216
User NOte:
Optimal dilutions for each application to be determined by the researcher.