Profilin-1 Antibody
Code | Size | Price |
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PSI-61-323-200ul | 200ul | £626.00 |
Quantity:
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Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Flow Cytometry
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Further Information
Additional Names:
Profilin-1, Epididymis tissue protein Li 184a, Profilin I, PFN1
Application Note:
For FACS starting dilution is: 1:25
For WB starting dilution is: 1:2000
For WB starting dilution is: 1:2000
Background:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
Background References:
- Kwiatkowski D.J.,et al.J. Biol. Chem. 263:5910-5915(1988).
- Li J.,et al.Mol. Cell. Proteomics 9:2517-2528(2010).
- Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
- Ota T.,et al.Nat. Genet. 36:40-45(2004).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This Profilin-1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 108-140 amino acids from the human region of human Profilin-1.
NCBI Gene ID #:
5216
NCBI Official Name:
Profilin-1
NCBI Official Symbol:
PFN1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
15 kDa
Protein Accession #:
P07737
Protein GI Number:
130979
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Neuroscience,Signal Transduction
Swissprot #:
P07737
User NOte:
Optimal dilutions for each application to be determined by the researcher.