RHO Antibody
| Code | Size | Price |
|---|
| PSI-58-850-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Rhodopsin, Opsin-2, RHO, OPN2
Application Note:
For WB starting dilution is: 1:1000
Background:
Retinitis pigmentosa is an inherited progressive disease
which is a major cause of blindness in western communities. It can
be inherited as an autosomal dominant, autosomal recessive, or
X-linked recessive disorder. In the autosomal dominant form,which
comprises about 25% of total cases, approximately 30% of families
have mutations in the gene encoding the rod photoreceptor-specific
protein rhodopsin. This is the transmembrane protein which, when
photoexcited, initiates the visual transduction cascade. Defects in
this gene are also one of the causes of congenital stationary night
blindness.
Background References:
- Clark, G.R., et al. Ophthalmology 117(11):2169-2177(2010)
- Li, S., et al. Biochem. Biophys. Res. Commun. 401(1):42-47(2010)
- Pulagam, L.P., et al. J. Biol. Chem. 285(38):29446-29456(2010)
- Audo, I., et al. Arch. Ophthalmol. 128(8):1036-1045(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Monkey
Immunogen:
This RHO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 310-339 amino acids from the C-terminal region of human RHO.
NCBI Gene ID #:
6010
NCBI Official Name:
Rhodopsin
NCBI Official Symbol:
RHO
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
39 kDa
Protein Accession #:
P08100
Protein GI Number:
129207
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction,Growth Factor
Swissprot #:
P08100
User NOte:
Optimal dilutions for each application to be determined by the researcher.