PLK2 Antibody
| Code | Size | Price |
|---|
| PSI-62-762-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Serine/threonine-protein kinase PLK2, Polo-like kinase 2, PLK-2, hPlk2, Serine/threonine-protein kinase SNK, hSNK, Serum-inducible kinase, PLK2, SNK
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For IHC-P starting dilution is: 1:50~100
Background:
Plks (polo-like kinases) encode serine/threonine kinases that are closely
related to polo and CDC5, genes that are required for passage through mitosis
in Drosophila and Saccharomyces, respectively. Polo-like kinases, which
include Plk, Snk (for serum-inducible kinase, also designated Plk2) and Fnk
(for FGF-inducible kinase, also designated Plk3 or PRK), play a role in cell
proliferation. Plk protein accumulates in the cell during S and G2 phases of
the cell cycle, and both protein content and catalytic activity peak at the
onset of mitosis, followed by a rapid reduction after mitosis. Snk and Fnk are
immediate-early response genes that are first expressed during G1 phase. SNK may play a role in the division of at least some cell types, such as fibroblasts, and could function in embryogenesis, wound healing or neoplasia SNK mRNA is rapidly induced in human lung fibroblasts upon reintroduction of serum following 36 hours of serum deprivation.
Background References:
- Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).
- Liby, K., et al., DNA Seq. 11:527-533 (2001).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PLK2 (SNK) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 375-406 amino acids from the C-terminal region of human PLK2 (SNK).
NCBI Gene ID #:
10769
NCBI Official Name:
Serine/threonine-protein kinase PLK2
NCBI Official Symbol:
PLK2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
78 kDa
Protein Accession #:
Q9NYY3
Protein GI Number:
22096374
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Signal Transduction
Swissprot #:
Q9NYY3
User NOte:
Optimal dilutions for each application to be determined by the researcher.