SF3B2 Antibody
| Code | Size | Price |
|---|
| PSI-58-322-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Splicing factor 3B subunit 2, Pre-mRNA-splicing factor SF3b 145 kDa subunit, SF3b145, SF3b150, Spliceosome-associated protein 145, SAP 145, SF3B2, SAP145
Application Note:
For WB starting dilution is: 1:2000
Background:
This gene encodes subunit 2 of the splicing factor 3b
protein complex. Splicing factor 3b, together with splicing factor
3a and a 12S RNA unit, forms the U2 small nuclear
ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a
complex binds pre-mRNA upstream of the intron's branch site in a
sequence-independent manner and may anchor the U2 snRNP to the
pre-mRNA. Splicing factor 3b is also a component of the minor
U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream
of the branch site at the anchoring site. Subunit 2 also interacts
directly with subunit 4 of the splicing factor 3b complex. Subunit
2 is a highly hydrophilic protein with a proline-rich N-terminus
and a glutamate-rich stretch in the C-terminus. [provided by
RefSeq].
Background References:
- Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
- Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
- Olsen, J.V., et al. Cell 127(3):635-648(2006)
- Olsen, J.V., et al. Cell 127(3):635-648(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SF3B2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 539-568 amino acids from the Central region of human SF3B2.
NCBI Gene ID #:
10992
NCBI Official Name:
Splicing factor 3B subunit 2
NCBI Official Symbol:
SF3B2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
100 kDa
Protein Accession #:
Q13435
Protein GI Number:
296452908
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q13435
User NOte:
Optimal dilutions for each application to be determined by the researcher.