MYBPC3 Antibody
| Code | Size | Price |
|---|
| PSI-56-426-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Myosin-binding protein C, cardiac-type, Cardiac MyBP-C, C-protein, cardiac muscle isoform, MYBPC3
Application Note:
For IHC-P starting dilution is: 1:25
For WB starting dilution is: 1:1000
For WB starting dilution is: 1:1000
Background:
MYBPC3 encodes the cardiac isoform of myosin-binding
protein C. Myosin-binding protein C is a myosin-associated protein
found in the cross-bridge-bearing zone (C region) of A bands in
striated muscle. MYBPC3, the cardiac isoform, is expressed
exclussively in heart muscle. Regulatory phosphorylation of the
cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon
adrenergic stimulation may be linked to modulation of cardiac
contraction. Mutations in MYBPC3 are one cause of familial
hypertrophic cardiomyopathy.
Background References:
- Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) :
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Millat, G., et al. EurMed Genet 53(5):261-267(2010)
- Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This MYBPC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-218 amino acids from the N-terminal region of human MYBPC3.
NCBI Gene ID #:
4607
NCBI Official Name:
Myosin-binding protein C, cardiac-type
NCBI Official Symbol:
MYBPC3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
141 kDa
Protein Accession #:
Q14896
Protein GI Number:
425906074
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q14896
User NOte:
Optimal dilutions for each application to be determined by the researcher.