Mouse Map2k4 Antibody

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ProSci
Product Code: PSI-58-100
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-58-100-400ul400ul£626.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Zebrafish
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).
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Western blot analysis in Y79 cell line lysates (35ug/lane).
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Mouse Map2k4 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded mouse cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
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Western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).
Western blot analysis in Y79 cell line lysates (35ug/lane).
Mouse Map2k4 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded mouse cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.

Documents

Further Information

Additional Names:
Dual specificity mitogen-activated protein kinase kinase 4, MAP kinase kinase 4, MAPKK 4, C-JUN N-terminal kinase kinase 1, JNK kinase 1, JNKK 1, JNK-activating kinase 1, MAPK/ERK kinase 4, MEK 4, SAPK/ERK kinase 1, SEK1, Map2k4, Jnkk1, Mek4, Mkk4, Prkmk4, Sek1, Serk1, Skk1
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50
Background:
Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1).
Background References:
  • Finegan, K.G., et al. Cancer Res. 70(14):5797-5806(2010)
  • Ahn, Y.H., et al. J. Biol. Chem. 284(43):29399-29404(2009)
  • Bogani, D., et al. PLoS Biol.(9), E1000196 (2009) :
  • Liu, W., et al. Circ. Res. 104(7):905-914(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Xenopus
Immunogen:
This Mouse Map2k4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 259-287 amino acids from the C-terminal region of mouse Map2k4.
NCBI Gene ID #:
26398
NCBI Official Name:
Dual specificity mitogen-activated protein kinase kinase 4
NCBI Official Symbol:
Map2k4
NCBI Organism:
Mus musculus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
44 kDa
Protein Accession #:
P47809
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction,
Swissprot #:
P47809
User NOte:
Optimal dilutions for each application to be determined by the researcher.