WWOX Antibody
| Code | Size | Price |
|---|
| PSI-57-993-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
WW domain-containing oxidoreductase, 111-, Fragile site FRA16D oxidoreductase, WWOX, FOR, WOX1
Application Note:
For WB starting dilution is: 1:1000
Background:
WW domain-containing proteins are found in all eukaryotes
and play an important role in the regulation of a wide variety of
cellular functions such as protein degradation, transcription, and
RNA splicing. This gene encodes a protein which contains 2 WW
domains and a short-chain dehydrogenase/reductase domain (SRD). The
highest normal expression of this gene is detected in hormonally
regulated tissues such as testis, ovary, and prostate. This
expression pattern and the presence of an SRD domain suggest a role
for this gene in steroid metabolism. The encoded protein is more
than 90% identical to the mouse protein, which is an essential
mediator of tumor necrosis factor-alpha-induced apoptosis,
suggesting a similar, important role in apoptosis for the human
protein. In addition, there is evidence that this gene behaves as a
suppressor of tumor growth. Alternative splicing of this gene
generates transcript variants that encode different isoforms.
Background References:
- Maeda, N., et al. Virchows Arch. 457(4):423-432(2010)
- Baykara, O., et al. Tumour Biol. 31(4):315-320(2010)
- Kurek, K.C., et al. Cancer Res. 70(13):5577-5586(2010)
- Lin, J., et al. Zhonghua Gan Zang Bing Za Zhi 18(5):357-360(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This WWOX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-396 amino acids from the C-terminal region of human WWOX.
NCBI Gene ID #:
51741
NCBI Official Name:
WW domain-containing oxidoreductase
NCBI Official Symbol:
WWOX
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
47 kDa
Protein Accession #:
Q9NZC7
Protein GI Number:
74725363
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Neuroscience
Swissprot #:
Q9NZC7
User NOte:
Optimal dilutions for each application to be determined by the researcher.