APC Antibody
| Code | Size | Price |
|---|
| PSI-60-427-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Adenomatous polyposis coli protein, Protein APC, Deleted in polyposis 25, APC, DP25
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a tumor suppressor protein that acts as
an antagonist of the Wnt signaling pathway. It is also involved in
other processes including cell migration and adhesion,
transcriptional activation, and apoptosis. Defects in this gene
cause familial adenomatous polyposis (FAP), an autosomal dominant
pre-malignant disease that usually progresses to malignancy.
Disease-associated mutations tend to be clustered in a small region
designated the mutation cluster region (MCR) and result in a
truncated protein product.
Background References:
- Chung, K.H., et al.Neurosurg Pediatr 6(4):372-376(2010)
- Rai, K., et al. Cell 142(6):930-942(2010)
- Poulogiannis, G., et al. Proc. Natl. Acad. Sci. U.S.A. 107(34):15145-15150(2010)
- Jaulin, F., et al. J. Cell Biol. 190(3):443-460(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This APC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1148-1176 amino acids from the Central region of human APC.
NCBI Gene ID #:
324
NCBI Official Name:
Adenomatous polyposis coli protein
NCBI Official Symbol:
APC
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
312 kDa
Protein Accession #:
P25054
Protein GI Number:
97535708
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Neuroscience,Signal Transduction
Swissprot #:
P25054
User NOte:
Optimal dilutions for each application to be determined by the researcher.