Mouse Txnip Antibody
| Code | Size | Price |
|---|
| PSI-60-886-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Thioredoxin-interacting protein, Vitamin D3 up-regulated protein 1, Txnip, Vdup1
Application Note:
For WB starting dilution is: 1:1000
Background:
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.
Background References:
- Kwon, H.J., et al. Toxicol. Appl. Pharmacol. 248(3):277-284(2010)
- Kwon, H.J., et al. J. Immunol. 185(7):3980-3989(2010)
- Ren, Y., et al. FEBS Lett. 584(15):3480-3485(2010)
- Chutkow, W.A., et al. Diabetes 59(6):1424-1434(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This Mouse Txnip antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-145 amino acids from the Central region of mouse Txnip.
NCBI Gene ID #:
56338
NCBI Official Name:
Thioredoxin-interacting protein
NCBI Official Symbol:
Txnip
NCBI Organism:
Mus musculus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
44 kDa
Protein Accession #:
Q8BG60
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Signal Transduction
Swissprot #:
Q8BG60
User NOte:
Optimal dilutions for each application to be determined by the researcher.